Details of Grant 

EPSRC Reference:	GR/S73105/01
Title:	Hypervalent Iodine Compounds
Principal Investigator:	Wirth, Professor T
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	Cardiff University
Scheme:	Standard Research (Pre-FEC)
Starts:	01 May 2004	Ends:	31 January 2008	Value (£):	196,286
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology Physical Organic Chemistry
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
In this research project the development of new chiral hypervalent iodine compounds and their application in asymmetric oxidation and oxygenation reactions is described. It is of high current interest to investigate their ability as highly selective oxidants, as electrophilic reagents and to develop new reactions using hypervalent iodine compounds. Because they are nonmetallic oxidation reagents, they avoid the issues of toxicity of many transition metals commonly involved in such processes. Therefore, hypervalent iodine compounds bear a high potential for the improvement of known reactions not only from the environmental and pharmaceutical point of view, they are also interesting reagents for the development of completely new synthetic transformations.The mechanism of those reactions will be studied in much more detail. To allow further optimization of the hypervalent iodine reagents, ab-initio calculations of both, the low energy conformations of the reagents and of electrophile-alkene complexes as important intermediates along the reaction pathway, will be investigated. New chiral hypervalent iodine compounds are to be synthesized and several new stereoselective reactions have to be explored. These investigations will culminate in the development of catalytic reactions which is also based upon the outcome of the research described above. Applications of this methodology to the synthesis of natural products or related target structures are further points of interest.
Key Findings
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Organisation Website:	http://www.cf.ac.uk