| EPSRC Reference: |
GR/S71880/01 |
| Title: |
An Experimental and Theoretical Study of Flow in Lymphatic Vessels |
| Principal Investigator: |
Tabor, Professor G |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Engineering Computer Science and Maths |
| Organisation: |
University of Exeter |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2004 |
Ends: |
31 March 2007 |
Value (£): |
157,323
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| EPSRC Research Topic Classifications: |
| Animal & human physiology |
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Summary on Grant Application Form |
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During the circulation of the blood fluid components are filtered out of the blood vessels into surrounding tissues. This fluid is returned to the general blood circulation via a network of vessels known as the lymph system. Failure of the lymph system due to disease or surgery can have disastrous consequences, including tissue swelling, impaired functioning of organs and breakdown of the immune system. Lymph flow is driven by the phasic contraction of segments of the vessel wall which are separated by passive, uni-directional valves. We have developed in vitro preparations in which we have extensively studied the physiology of the lymphatic vessels. We now propose to extend this study with measurements of the essential fluid mechanical parameters such as local pressures, wall geometry and mechanical properties, flow visualisation and computational modelling to investigate flow in individual lymph vessels and in lymph networks. In this, the first study to link all of these techniques, we shall establish the influence of a range of physiological parameters on pumping efficiency. The data obtained will be of value in understanding many medical conditions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ex.ac.uk |