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Details of Grant 

EPSRC Reference: GR/S71637/01
Title: Reactivity and Function of Diaqua Lanthanide Complexes
Principal Investigator: Parker, Professor D
Other Investigators:
Dickins, Dr R
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: Durham, University of
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2004 Ends: 30 September 2007 Value (£): 189,792
EPSRC Research Topic Classifications:
Chemical Biology Gas & Solution Phase Reactions
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
The elaboration of the reaction chemistry of diaqua lanthanide complexes in aqueous media, in which inter or intramolecular binding of selected anions is examined as a function of anion concentration/pH. Control over binding affinity is achieved by tailoring complex structure and by permutation of the Ln ion itself. The function of these complexes include an optical pH probe suitable for minituarisation using pH or pZn switched sulfonamide ligation, a sensitive MRI method for measuring pZn in the nanomolar range and an exploration of the reactivity of chelated alpha-ketoacids (pyruvate, oxaloacetate, 2-oxyglutarate), or keto-amides with a view to enantioselective catalysis of reduction or reductive amination.
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