| EPSRC Reference: |
GR/S66701/01 |
| Title: |
APPLICATION OF THE MATHEMATICAL MODELLING OF ACTIVE CELL MOTION TO CELL/BIOMATERIAL SYSTEMS |
| Principal Investigator: |
Grant, Professor DM |
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| Department: |
Sch of Mech Materials Manuf Eng Mgt |
| Organisation: |
University of Nottingham |
| Scheme: |
Postdoctoral Mobility PreFEC |
| Starts: |
01 November 2003 |
Ends: |
31 October 2004 |
Value (£): |
47,752
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| EPSRC Research Topic Classifications: |
| Biomaterials |
Biophysics |
| Tissue Engineering |
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Summary on Grant Application Form |
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Self-propelled cell migration over surfaces and through tissues is fundamental to many biological phenomena and is essential for the colonisation of biomaterial scaffolds in tissue engineering and of orthopaedic implants and fixation devices after surgery.We aim to continue a collaboration between mathematicians, material scientists and bioscientists (at the University of Nottingham) to quantify further (i) the dynamics of the main components of an animal cell responsible for motility (which are similar for many species), (ii) how these components are controlled and coordinated by the intricate underlying molecular biology, and(iii) the implications of the results for specific cell/biomaterial systems relevant to the healthcare community.We propose to write a numerical code to calibrate and test the limitations of our recently developed theoretical cell-scale model (by quantitative comparison with existing and ongoing motility experiments), and thereby develop more sophisticated submodels for the underlying molecular biology and cell morphology.The interdisciplinary nature of this project will facilitate the transfer of theoretical modelling and experimental simulation capabilities between the theoreticians and experimentalists; this approach is essential if researchers are to understand cell motility fully and to facilitate thereby the development of a second generation of implant materials.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |