Details of Grant 

EPSRC Reference:	GR/S64042/01
Title:	An Improved Clinical High Intensity Focused Ultrasound (FUS) Prototype Device
Principal Investigator:	ter Haar, Professor GRt
Other Investigators:	Bamber, Professor JC
Researcher Co-Investigators:	Professor P Friend Dr IH Rivens
Project Partners:	IMASONIC SAS Royal Marsden Hosp/NHS Trust University of Oxford
Department:	Physics
Organisation:	Institute of Cancer Research
Scheme:	Standard Research (Pre-FEC)
Starts:	01 April 2004	Ends:	29 February 2008	Value (£):	795,705
EPSRC Research Topic Classifications:	Med.Instrument.Device& Equip.
EPSRC Industrial Sector Classifications:	Healthcare
Related Grants:
Panel History:
Summary on Grant Application Form
High intensity focused ultrasound (FUS) has been developed at the Institute of Cancer Research, Sutton for the treatment of soft tissue tumours.The technique allows high power ultrasound to be focused into a target region (e.g. part of a tumour) using a source located outside the body. The heat generated at the focus can kill cancer cells within seconds.To date we have developed and clinically tested a prototype system. In Department of Health funded clinical trials we have shown that treatment is well tolerated by patients and can be effective for treating solitary liver tumours. The treatment of over 70 patients has given us the experience necessary to now improve our relatively simple first prototype system.Using laboratory models we aim to develop automated methods of treatment delivery which significantly speed up treatment in order that larger tumours may be completely eradicated. We also propose to develop a novel FUS source which will allow the treatment of tumours which are currently inaccessible. Combined FUS and diagnostic ultrasound imaging will greatly simplify target identification and treatment monitoring. We will also implement novel imaging techniques for monitoring the treated volume which have been investigated in a current EPSRC grant. This will be done firstly for monitoring the treated volume and secondly to examine their potential for improving acousto-thermal dosimetry.
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Organisation Website:	http://www.icr.ac.uk