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Details of Grant 

EPSRC Reference: GR/S62505/01
Title: Next Generation Pharmaceuticals: Linking Novel Engineering & Chemistry to a Revolution in Biocatalysis
Principal Investigator: Lye, Professor G
Other Investigators:
Ward, Professor JM Baganz, Dr F Dalby, Professor PA
Hailes, Professor HC
Researcher Co-Investigators:
Project Partners:
Department: Biochemical Engineering
Organisation: UCL
Scheme: Standard Research (Pre-FEC)
Starts: 01 February 2004 Ends: 31 January 2008 Value (£): 1,686,303
EPSRC Research Topic Classifications:
Bioprocess Engineering
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
Food and Drink
Related Grants:
Panel History:  
Summary on Grant Application Form
The proposed research sets out to establish a systematic approach to achieving integration of chemical, biocatalytic and bioprocess issues and to demonstrate its value with representative advanced systems. This will be achieved by the interdisciplinary linkage of a number of new approaches, including: Biochemical engineering studies to define the performance of microwells for research on complete biocatalytic processes. Metabolic engineering integrated with chemical approaches. Original directed evolution concepts such as focussed error prone PCR and substrate walking to enhance enzyme performance. Modelling of the catalyst and process parameters to yield a form of output which is readily interpretable.The integration of these new approaches will allow additional novel objectives to be achieved. Thus: The automation of the microwell experimental systems will be exploited to create a direct linkage to modelling of catalyst and process performance. Fast and compatible microwell systems for both biocatalyst and bioprocess studies will be used to achieve a higher level of performance.Taken together these approaches will make it possible to define a generic framework to support the individual goals of company partners. The research will have particular application in planning how to choose quickly the best approach for a new potential target substance.
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