Details of Grant 

EPSRC Reference:	GR/S57785/01
Title:	Stereochemical Communication: Relaying Information by Conformational Interactions
Principal Investigator:	Clayden, Professor J
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	University of Manchester, The
Scheme:	Standard Research (Pre-FEC)
Starts:	01 March 2004	Ends:	31 October 2007	Value (£):	246,926
EPSRC Research Topic Classifications:	Asymmetric Chemistry Physical Organic Chemistry
EPSRC Industrial Sector Classifications:	Pharmaceuticals and Biotechnology
Related Grants:
Panel History:
Summary on Grant Application Form
Stereochemistry can be viewed as binary information, and stereocontrol as the communication of that information through space. Reliable stereochemical control is mediated by conformation, and empirically it is clear that better control of conformation yields higher stereoselectivity. In this project we propose to develop the methods of stereocontrol and apply them more generally to the problem of communicating information through space, mediated not by electronics but by conformation. We shall identify molecular fragments whose conformation is readily controlled by local stereochemistry, and which are able to propagate conformation through a molecule by a series of relayed interactions. Conformational communication not a concept familiar in chemistry, but is central to the phenomenon of allostery in biology. In an allosteric protein, haemoglobin being the classic example, the binding of a ligand leads to a conformational change which propagates through the molecule, leading to a remote alteration of stereochemistry (conformation) and hence modulating the binding affinity of further ligands. Conformational changes in transmembrane proteins likewise communicate information between binding sites on opposite sides of the membrane. As chemists, we aim to design conformationally linked receptors and effectors and demonstrate the ootential for chemical allosterv in information transfer and orocessino.
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Organisation Website:	http://www.man.ac.uk