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Details of Grant 

EPSRC Reference: GR/S53480/02
Title: Synthesis of the Thiopeptide Antibiotic Nosiheptide, a Heterocyclic Peptide Macrocycle
Principal Investigator: Moody, Professor CJ
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Nottingham
Scheme: Standard Research (Pre-FEC)
Starts: 01 August 2005 Ends: 31 March 2006 Value (£): 73,092
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Chemical Synthetic Methodology
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
The target of this proposal, the antibiotic nosiheptide, is a member of the thiopeptide family of antibiotics, a growing class of sulfur containing modified cyclic peptides with pronounced biological activity against Gram-positive bacteria and, anaerobes, including pathogens resistant to agents in current use, and also against the malaria parasite. The thiopeptides are of major biological significance; most are powerful inhibitors of protein synthesis in bacteria with novel modes of action.The planned synthesis combines new chemistry (Diels-Alder reactions of vinyloximes) with chemistry pioneered in our own laboratory (carbene N-H insertion, chiral oxime ethers) to obtain the key fragments of the natural product - a 2,3,4-trisubstituted indole, a 2,3,5,6-tetrasubstituted pyridine, and two thiazole containing fragments, which are subsequently coupled together into the double macrocyclic array of nosiheptide.
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Organisation Website: http://www.nottingham.ac.uk