| EPSRC Reference: |
GR/S40442/01 |
| Title: |
Stereocontrolled Fragment Linkage Reactions Using pi-Allymetal Complexes |
| Principal Investigator: |
Kocienski, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 August 2003 |
Ends: |
31 July 2006 |
Value (£): |
331,140
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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We aim to develop planar chiral cationic allylmolybdenum complexes for use in fragment linkage reactions. The reactions are notable because (a) they work in highly hindered steric environments where existing methods fail, (b) they are not subject to the complications attending mismatched pairs when chiral substrates and reactants are used and (c) they work with relatively hard organometallic nucleophiles beyond the pale of Pd chemistry. Some new reagents recently developed in Leeds for the synthesis of chiral molybdenum complexes are now applicable to highly substituted and functionalised substrates. The scope, stereochemistry and regiocehmistry of the addition of C-nucleophiles to the molybdenum complexes will be explored in the context of 4 challenging natural products each of which illuminates a different facet of the reaction.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |