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Details of Grant 

EPSRC Reference: GR/S30269/01
Title: The Liliaceae - a potential source of new anti-tubercular drug-leads
Principal Investigator: Gibbons, Professor S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: School of Pharmacy
Organisation: UCL
Scheme: Standard Research (Pre-FEC)
Starts: 27 October 2003 Ends: 26 October 2006 Value (£): 86,789
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Medical science & disease
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
30 Jan 2003 Chemistry Prioritisation Panel (Science) Deferred
Summary on Grant Application Form
The World Health Organisation has estimated that tuberculosis kills over two million people each year and represents a global epidemic that is worsening due to the occurrence and proliferation of strains of multidrug-resistant (mdr) Mycobacterium tuberculosis. New agents are urgently needed to meet the threat of mdr tuberculosis and to manage infection with the naturally resistant non-tuberculosis fast growing mycobacteria. Outbreaks in major cities such as New York, and more recently in a School in Leicester in the UK, highlight the need for new chemistry for what was previously regarded as a third-world problem.This research proposal seeks funding to investigate the anti mycobacterial properties of extracts from plants belonging to the genus Allium, which we have shown to have good activity against Mycobacterium fortuitum, a model assay for the characterisation of anti-tubercular drugs. Research will focus on the isolation and characterisation of compounds that have activity against a panel of fast growing strains of Mycobacterium, and pure compounds will be evaluated against strains of M. tuberculosis, at the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF), in Birmingham, Alabama, USA. Most importantly, the proposed research will train a student in the interdisciplinary subject of Phytochemistry.
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