| EPSRC Reference: |
GR/S30177/01 |
| Title: |
Desymmetrising Centrosymmetric Molecules by C-C Bond Formation: A Total Synthesis of Hemibrevetoxin B |
| Principal Investigator: |
Nelson, Professor AS |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
26 January 2004 |
Ends: |
25 March 2006 |
Value (£): |
120,265
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Established routes to complex polyether natural products involve the painstaking, iterative synthesis of the individual ring systems. Many of these natural products contain embedded centrosymmetric fragments. Despite this, reported syntheses have not exploited this hidden symmetry. We will exploit the desymemtrisation of a centrosymemtric molecule for the first time in a total synthesis: an enatioselective C-C bond-forming reaction will be used as a key step in a convergent, efficient synthesis of Hemibrevetoxin B.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |