| EPSRC Reference: |
GR/S26279/01 |
| Title: |
Multicomponent Catalysis |
| Principal Investigator: |
Gibson, Professor SE |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2003 |
Ends: |
30 September 2006 |
Value (£): |
114,238
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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| Panel History: |
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Summary on Grant Application Form |
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Living organisms synthesise most of their required metabolites by a programmed sequence of enzyme-catalysed reactions that show high speci towards the different intermediates involved. Successful mimicking of this strategy using chemical catalysts would provide synthetic chemists w conceptually new approach to the design of new reactions; moreover, in the long term, it could also provide economically attractive industrialprocesses that mimimise the use of chemicals and solvents, the production of waste and processing time.Although the concept of multicomponent catalysis is very attractive, the approach presents many challenges and it is perhaps not surprising that there are only a handful of examples of its successful execution to date.In this proposal, we present five ideas for the concurrent operation of two catalysts. The proposed systems, which effectively represent five new reactions, are dominated by the Pauson-Khand reaction, partly because we have recently developed a robust and effective catalyst for this reac that operates under mild and neutral conditions and has been shown to be effective on a large scale, and partly because it is an attractive carbo carbon bond-forming reaction, forming synthetically important cyclopentenones from an alkyne, an alkene and carbon monoxide.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |