Details of Grant 

EPSRC Reference:	GR/S22660/01
Title:	Peripherally-Functionalised Porphyrazines: Novel Metallomacrocycles with Broad Untapped Potential
Principal Investigator:	Barrett, Professor T
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Chemistry
Organisation:	Imperial College London
Scheme:	Standard Research (Pre-FEC)
Starts:	01 November 2003	Ends:	31 October 2006	Value (£):	267,567
EPSRC Research Topic Classifications:	Chemical Synthetic Methodology Drug Formulation & Delivery
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
Related Grants:
Panel History:
Summary on Grant Application Form
Peripherally functionalised porphyrazines (tetraazaporphyrins) form a distinct class of novel macrocycles isoelectronic with porphine, but by comparison have been little studied. They are prepared by the template cyclisation of maleonitrile derivatives rather than the condensation of pyrrole and aldehydes. They exhibit substantially different electronic properties from porphyrins. In consequence porphyrazines offer the potential to access new classes of macrocycles virtually inaccessible in the porphyrin family. Heteroatom centred groups fused directly to the S-positions of the pyrrole units show strong coupling to the macrocycle core with the attendant tailorable and varied solubility and electronic, optical, magnetic, redox and biological properties. The research in this proposal will address two distinct topics: (1) the synthesis and characterization of aminoporphyrazine solitaire and Gemini complexes including porphyrazine-salen, porphyrazine-(salen)2 and (porphyrazine)2-salensystems and (2) the development of biomedical applications of porphyrazines for the diagnosis of cancer, in photodynamic therapies for cancer and infectious disease and as molecular probes in developmental biology. This dual approach will allow for the discovery of structurally novel classes of multimetallic porphyrazine metal complexes and, in parallel, the development of important biomedical applications for classes of metalloporphyrazines developed in the last decade in the Barrett and Hoffman laboratories.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk Summary Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:
Further Information:
Organisation Website:	http://www.imperial.ac.uk