| EPSRC Reference: |
GR/S16393/01 |
| Title: |
Bypassing Epoxides: Novel Strategies for the Direct Carbo-Hydroxylation of Alkenes |
| Principal Investigator: |
Booker-Milburn, Professor KI |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
16 June 2003 |
Ends: |
15 August 2005 |
Value (£): |
116,713
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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This research aims to develop a new strategy to (3-substituted alcohols based on the concept of the direct carbo-hydroxylation of alkenes. In the first instance we intend to investigate the Pd(0) catalysed Heck type additions of o-iodophenyldimethyl silanol to alkenes and dienes. It is anticipated that the intermediate carbometallation product will form a palladium heterocycle before (3-hydride elimination can proceed. This species should then undergo reductive elimination to form a S-O based heterocycle which upon protodesilylation on workup will afford the (3-substituted alcohol. This methodology could offer an alternative to the more usual sequence of alkene epoxidation followed by ring opening with a carbon nucleophile. Possibilities to tune the mechanism in favour of our goal will exist by suitable modification of ligands and use of appropriate additives. If successful this methodology will be adapted to cover the carbo-amination of alkenes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |