EPSRC logo

Details of Grant 

EPSRC Reference: GR/S08916/01
Title: Modelling and understanding of immature brain development using statistical models of shape and appearance
Principal Investigator: Rueckert, Professor D
Other Investigators:
Hajnal, Professor JV Edwards, Professor D Rutherford, Professor M
Researcher Co-Investigators:
Project Partners:
Department: Dept of Computing
Organisation: Imperial College London
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2003 Ends: 31 March 2006 Value (£): 257,204
EPSRC Research Topic Classifications:
Biomedical neuroscience Image & Vision Computing
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
Over 60% of infants born below 26 weeks gestational age show signs of neuro-developmental impairment. In 10-20% this is a predominantly motor impairment or cerebral palsy but in the remainder the impairment is neuro-cognitive or neuro-behavioural. The infant born pre-term is exposed to numerous potentially damaging factors such as infection, drugs, hypoxia, and inadequate nutrition, and deprived of the normal intrauterine environment. Pre-term delivery is often due to infection, which may also have a profound effect on the developing brain. Currently, the mechanisms for this and the effects of various forms of treatment during the neonatal care on the neuro-developmental impairment are not well understood.In this proposal, we aim to build a statistical model of the normal neuroanatomy and its growth patterns during the early stages of development. Using a group of 30 to 50 pre-term infants without abnormalities we will construct a statistical model of the development of brain shape and appearance in form of an atlas. This atlas will describe the normal development in brain anatomy and will act as a reference space in which to compare growth patterns from different subjects. The construction of such a statistical model of neonatal anatomy and growth patterns will require the development of novel computational techniques for non-rigid registration and computational morphometry. We will combine the development of these techniques with expert knowledge of the developing brain
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.imperial.ac.uk