| EPSRC Reference: |
GR/S07667/01 |
| Title: |
Synthetic utility of (perfluoroaryl)boryl reagents: B-C and C-C bond forming reactions |
| Principal Investigator: |
Aldridge, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Cardiff University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2003 |
Ends: |
30 September 2006 |
Value (£): |
77,308
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| EPSRC Research Topic Classifications: |
| Catalysis & Applied Catalysis |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The controlled functionalization of unactivated C-H bonds has long been one of the'Holy Grails' of chemical synthesis. The contribution of organometallic chemistry to this area has been given added impetus by the recent discovery of selective hydrocarbon functionalization (to boronate esters) under both stoichiometric and catalytic conditions via transition metal boryl complexes. In preliminary work we have synthesised the first examples of transition metal complexes containing electrophilic perfluorinated boryl ligands, and recently discovered that these complexes act as stoichiometric reagents for the transfer of the boryl fragment to arene C-H bonds. We propose to extend this chemistry to investigate further the selectivity, activity and mechanism of this stoichiometric functionalization reaction. This work will be developed further to probe the possibility for a catalytic variant using the hydride [HB(C6F5)2]2. Such reactivity ha; precedent in alkane functionalization chemistry and offers a facile new route to electrophilic boranes of potential use in anion recognition, olefin polymerisation catalysis and C-C bond forming reactions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.cf.ac.uk |