| EPSRC Reference: |
GR/S03942/01 |
| Title: |
Application of FTIR Spectroscopic Imaging to Drug Release |
| Principal Investigator: |
Kazarian, Professor SG |
| Other Investigators: |
|
| Researcher Co-Investigators: |
|
| Project Partners: |
|
| Department: |
Chemical Engineering |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
17 March 2003 |
Ends: |
16 March 2005 |
Value (£): |
116,749
|
| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Drug Formulation & Delivery |
| Materials Characterisation |
|
|
| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
|
|
| Related Grants: |
|
| Panel History: |
|
|
Summary on Grant Application Form |
|
The programme of work will explore the applications of FTIR Imaging to study controlled drug release. Specifically, this proposal is aimed at elucidation of the dynamic processes in drug release from formulations in water-soluble polymers (diffusion, polymer degradation and drug release) via FTIR Imaging spectroscopy. This method relies on the ability of the Infrared array detector to simultaneously measure spectra from 4096 different locations in a sample. FTIR Imaging spectroscopy will be applied in situ for the first time to examine drug release from polymer/drug formulations by simultaneous measuring the large area at the interface between biodegradable polymers (containing drugs) and water as a function of time. A broader aim is to facilitate the use of spectroscopic FTIR imaging technology for preparation of solid dispersions by revealing the underlying principles of polymer/solvent interactions and its relevance to controlled drug release processes. Preliminary work has already been carried with a biodegradable polymer, and our results are very exciting and very promising.
|
|
Key Findings |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Potential use in non-academic contexts |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
|
Impacts |
|
| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
|
| Date Materialised |
|
|
|
|
Sectors submitted by the Researcher |
|
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
|
| Project URL: |
|
| Further Information: |
|
| Organisation Website: |
http://www.imperial.ac.uk |