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Details of Grant 

EPSRC Reference: GR/S03942/01
Title: Application of FTIR Spectroscopic Imaging to Drug Release
Principal Investigator: Kazarian, Professor SG
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Department of Chemical Engineering
Organisation: Imperial College London
Scheme: Standard Research (Pre-FEC)
Starts: 17 March 2003 Ends: 16 March 2005 Value (£): 116,749
EPSRC Research Topic Classifications:
Biological & Medicinal Chem. Drug Formulation & Delivery
Materials Characterisation
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:  
Summary on Grant Application Form
The programme of work will explore the applications of FTIR Imaging to study controlled drug release. Specifically, this proposal is aimed at elucidation of the dynamic processes in drug release from formulations in water-soluble polymers (diffusion, polymer degradation and drug release) via FTIR Imaging spectroscopy. This method relies on the ability of the Infrared array detector to simultaneously measure spectra from 4096 different locations in a sample. FTIR Imaging spectroscopy will be applied in situ for the first time to examine drug release from polymer/drug formulations by simultaneous measuring the large area at the interface between biodegradable polymers (containing drugs) and water as a function of time. A broader aim is to facilitate the use of spectroscopic FTIR imaging technology for preparation of solid dispersions by revealing the underlying principles of polymer/solvent interactions and its relevance to controlled drug release processes. Preliminary work has already been carried with a biodegradable polymer, and our results are very exciting and very promising.
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Organisation Website: http://www.imperial.ac.uk