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Details of Grant 

EPSRC Reference: GR/S00811/01
Title: Synthetic Studies on Dienediyne Chromoprotein Antibiotics
Principal Investigator: Caddick, Professor S
Other Investigators:
Woolfson, Professor DN
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: UCL
Scheme: Standard Research (Pre-FEC)
Starts: 01 October 2003 Ends: 31 March 2007 Value (£): 229,303
EPSRC Research Topic Classifications:
Biological & Medicinal Chem.
EPSRC Industrial Sector Classifications:
Healthcare Pharmaceuticals and Biotechnology
No relevance to Underpinning Sectors Chemicals
Related Grants:
Panel History:  
Summary on Grant Application Form
The dienediyne chromoprotein antibiotics are a class of highly reactive and potent anticancer agents which have found use in the clinic for the treatment of pancreatic cancer. These natural products are isolated from soil bacteria as a natural complex comprising the chromophore non-covalently bound to the apoprotein. The purpose of this project is to assemble core sub-structures of the dienediynes using novel radical, metathesis and aldol chemistry. Recombinant technology has been used to provide access to the apo-protein of NCS and this will be utilised to stablise late-stage intermediates in the planned synthesis of Neocarzinostatin, this would be a novel approach to total synthesis. The work will develop new methods for synthesis and will also underpin ongoing biological studies.
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