| EPSRC Reference: |
GR/R91922/01 |
| Title: |
Asymmetric homologation of boronic esters with configurationally stable chiral carbenoids |
| Principal Investigator: |
Marsden, Professor SP |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 January 2003 |
Ends: |
31 December 2005 |
Value (£): |
65,029
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Simple 1 chloroalkylmagnesium reagents possess exceptional configurational stability and have been recently synthesised by Hoffmann in enantioenriched form by sufoxide ligand exchange. We aim to investigate the insertion reactions of such carbenoids with boronic esters arid to develop an iterative asymmetric synthetic technique based on the anticipated reagent controlled homlogation processes. The proposed methodology is totally programmable and offers a degreeof efficiency riot possible with existing substrate controlled asymmetric boronic ester homologation technology. The research programme Will place an emphasis on the development of carbenoid reagents (1 chloroethylmagnesium bromide arid chloro(dimethylphenylsily)methylmagnesium bromide) suitable for the __asymmetric elaboration of polypropionate and polyol chains; structural features inherent to many important biologically active natural products arid particularly evident in the polyketides. The reagent controlled asymmetric homologation reactions of polymer supported boronic esters will be investigated at a later stage of the project. Finally, the methodology developed during earlier phases of the project will be exploited to synthesise a significant fragment of the complex polyketide discodermolide.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |