| EPSRC Reference: |
GR/R89875/01 |
| Title: |
Programmed assembly of DNA- coupled nanoparticles and nanoparticle-protein networks |
| Principal Investigator: |
Mann, Professor S |
| Other Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 April 2003 |
Ends: |
31 March 2006 |
Value (£): |
181,035
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Biology |
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| EPSRC Industrial Sector Classifications: |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The goal of this proposal is to use the programmed self-assembly of small building blocks to produce functionalized structures with potential applications in bionanotechnology. Over the period of the grant, networks of gold nanoparticles will be constructed by crosslinking procedures using base-pairing interactions between complementary oligonucleotides. Moreover, by using well-defined rod-shaped nanoparticles, this approach will produce organized assemblies with intrinsic anisotropy, and hence have particular potential in devices that exhibit orientation-dependant physical properties. We intend to use these programmable building units to construct nanostructures which comprise multiple components with different composition (Au, Ag, CdSe nanoparticles) and shape (rods and spheres), as well as connecting units with enhanced functionality (biotinylated DNA linkers with coupled proteins, antibodies, haptens) for sensor-based applications. The positioning of proteins between programmable nanoparticles arranged as arrays and spaced at certain distances apart, should be of immediate advantage compared with current methods that employ surface-adsorbed polypeptides, because the proteins will not be denatured by contact with the metallic surface.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |