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Details of Grant 

EPSRC Reference: GR/R89172/02
Title: The Development of Modulated Thermal Methods for the Characterisation of Amorphous Pharmaceuticals
Principal Investigator: Craig, Professor D
Other Investigators:
Kett, Dr V Reading, Dr M
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of East Anglia
Scheme: Standard Research (Pre-FEC)
Starts: 01 September 2003 Ends: 30 April 2005 Value (£): 104,737
EPSRC Research Topic Classifications:
Chemical Biology Drug Formulation & Delivery
EPSRC Industrial Sector Classifications:
Pharmaceuticals and Biotechnology
Related Grants:
Panel History:  
Summary on Grant Application Form
It is well recognized that the current knowledge base regarding amorphous pharmaceuticals is insufficient, particularly in terms of the predictability of behaviour from physico-chemical measurements and the establishment of the variability of the nature of amorphous material in relation to previous processing, both with wholly amorphous pharmaceuticals and partially crystalline materials. In this project the novel technique of Tzero DSC will be studied in conjunction with a range of supportive methods in order to provide fundamental information on the glass transition, heat capacity change, relaxation behaviour and plasticization profile for three model drugs, prepared in either a wholly amorphous state via different processing routes or in a partially crystalline state via size reduction. These fundamental parameters will be related to subsequent behaviour in terms of crystallisation, dissolution and vapour sorption. In this manner the influence of processing on the glassy state in relation to both structure and product performance will be established. In addition the use of Tzero as a novel pharmaceutical tool will be established. In parallel to this we propose to run a postgraduate study whereby micorthermal analysis will be employed to study partially crystalline systems with a particular view to imaging regions of amorphous material.
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