| EPSRC Reference: |
GR/R87901/01 |
| Title: |
Basic Technology: Deep, time-resolved imaging in aberrant biological media by adaptive and predictive wave-front correction |
| Principal Investigator: |
Vojnovic, Professor B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Advanced Technology Development Group |
| Organisation: |
Gray Cancer Institute |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2002 |
Ends: |
30 September 2006 |
Value (£): |
1,172,792
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| EPSRC Research Topic Classifications: |
| Image & Vision Computing |
Lasers & Optics |
| Optical Phenomena |
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| EPSRC Industrial Sector Classifications: |
| Electronics |
Creative Industries |
| Pharmaceuticals and Biotechnology |
Information Technologies |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Acquisition of accurate, minimally invasive images for diagnostic or prognostic use in clinical and biochemical research is of major significance, particularly in cancer research. This proposal deals with the development, application and integration of optical and software methods to enable imaging of phenomena as diverse as cell signalling pathways, tissue optical `signatures' and characterisation of clinically relevant pathologies. It focuses on development of enabling technologies towards their application in integrated and optimised multi-parametric, multiphoton macro- and microscopy apparatus incorporating the elements of adaptive optics, portability, time-domain spectroscopy and on-line analysis. The primary aim is to develop practical means of deep tissue imaging with initial applications in microscopy but with eventual applications in clinical practice. The developments will include: (1) diffraction-limited 3-D fluorescence lifetime and spectral imaging at depth in biological samples and living tissue; (2) optimised multiphoton imaging apparatus combining the elements of dynamic adaptive optics, advanced modalities and ps lifetime transient imaging; (3) an integrated system to provide multi-parametric data analysis through intelligent auto-segmentation, local and global analysis, for determination of analyte concentration, fluorescence lifetime and anisotropy, with applications for pharmacokinetics and drug diffusion studies and (4) development of robust and easy to operate solid-state femto/picosecond laser sources.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.graylab.ac.uk |