Details of Grant 

EPSRC Reference:	GR/R86744/01
Title:	New Hydroxamic Acid Ligands for Asymmetric catalysis
Principal Investigator:	Malkov, Professor A
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	School of Chemistry
Organisation:	University of Glasgow
Scheme:	Fast Stream
Starts:	01 October 2002	Ends:	30 September 2005	Value (£):	63,066
EPSRC Research Topic Classifications:	Co-ordination Chemistry
EPSRC Industrial Sector Classifications:	Chemicals Pharmaceuticals and Biotechnology No relevance to Underpinning Sectors
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Panel History:
Summary on Grant Application Form
New efficient chiral ligands with the hydroxamic acid core will be designed for vanadium catalysed asymmetric epoxidation and related Lewis acid catalysed reactions. The purpose of this project is to overcome the notorious in vanadium epoxidation catalysis ligand deceleration effect and improve enantioselectivity. The research will be inspired by our preliminary results which show substantial acceleration and modest to good enantioselectivity. The role of various structural features on the effectiveness of the reaction will be studied. The accelerating effect of an additional functional group in the ligand on the reactivity, combined with the effect of chirality relay by substituted amide observed for related systems, should lead to the development of new very effective catalytic epoxidation systems based on vanadium complexes.
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Organisation Website:	http://www.gla.ac.uk