| EPSRC Reference: |
GR/R82883/01 |
| Title: |
Chemical Predisposition: Divergent Synthesis of an Array of Natural and Unnatural Fatty Acid Derivatives |
| Principal Investigator: |
Whitehead, Dr R |
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| Department: |
Chemistry |
| Organisation: |
University of Manchester, The |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 2002 |
Ends: |
31 December 2004 |
Value (£): |
115,838
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The plakorsins, untenone A and the manzamenones are a varied array of bioactive, fatty acid derived natural products which have all been isolated from plakortis sponges. It is our proposal, that these compounds are all derived from a common biosynthetic precursor, the highly cytotoxic peroxy ketal, chondrillin, which was first isolated from a chrondrilla sponge in 1976 and subsequently from a plakortis sponge in 1990. A conceptually simple series of transformations, which exploit the inherent reactivity of chrondrillin, are proposed to provide a biosynthetic link between this intriguing natural product and the other fatty acid derivatives. The ultimate aim of our proposed research is to prepare all of the natural fatty acid derivatives, as well as a range of unnatural analogues, in a clean and efficient manner from chondrillin using an approach modeled on our biogenetic theory. The brevity of our proposed route will allow the preparation of significant quantities of both natural and unnatural materials which will be assessed for their toxicity towards a range of cancer cell lines.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.man.ac.uk |