| EPSRC Reference: |
GR/R79159/01 |
| Title: |
Developing the Hydroxy-Amination of Functionalised Alkenes |
| Principal Investigator: |
Donohoe, Professor T |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Oxford Chemistry |
| Organisation: |
University of Oxford |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
20 October 2002 |
Ends: |
19 October 2004 |
Value (£): |
116,292
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed work describes an investigation into the directed hydroxyarnination reaction. By tethering the nitrogen source to an allylic alcohol or amide we will be able to achive control of the stereo- and regiochernistry of subsequent hydroxyarnination reactions. All aspects of acyclic and cyclic sterocontrol will be investigated, as will the role of the atoms in the tether and of chiral ligands. Development of such a procedure is important because it extends the range of a versatile, catalytic and environmentally friendly reaction and should allow the preparation of biologically active derivatives in an efficient and succinct fashion. Longer term goals of this work include a study into alternative chiral auxiliaries capable of influencing the hydroxyarnination reaction and the successful development of this aspect of the work could lead to a new and powerful method of peptide synthesis whereby growing peptide chains are prepared from a series of substituted alkenes.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ox.ac.uk |