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Details of Grant 

EPSRC Reference: GR/R76219/02
Title: Synaptic Travelling Waves
Principal Investigator: Coombes, Professor S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Mathematical Sciences
Organisation: University of Nottingham
Scheme: Advanced Fellowship (Pre-FEC)
Starts: 01 October 2003 Ends: 30 September 2007 Value (£): 188,198
EPSRC Research Topic Classifications:
Non-linear Systems Mathematics
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
An important goal of neuroscience is to establish a series of direct links between the abstract nature of biophysical model equations and their interpretation in terms of experimental findings in biological neural networks. I propose to address this issue by developing a novel mathematical analysis of the dynamics of synaptically interacting neural systems and by establishing a framework for comparison with experimental measures of neural activity. The focus of the study will be on travelling waves and spatially structured activity observed in cortex during epileptic seizures, the travelling spindle waves observed in thalamus at the onset of sleep or drowsiness and waves of activity in animal motor systems. The understanding of the mechanisms for such a wide range of both pathological and naturally occuring phenomena is directly relevant to both improved clinical treatments and the understanding of the role of dynamics in neurobiological function. Since neuronal rhythmic activity also manifests itself in various aspects of normal brain function, that include synchronisation and waves of excitation observed in cortex during sensory processing, the work will have broad application in the neurosciences.The work is based around an interplay between new mathematics and its biological and clinical application.
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Organisation Website: http://www.nottingham.ac.uk