Details of Grant 

EPSRC Reference:	GR/R74130/01
Title:	A Novel 3-Dimensional Polymer-based Pyrolysed Carbon Filtration/Adsorbent Device for the Treatment of Sepsis
Principal Investigator:	Lloyd, Professor AW
Other Investigators:	Olliff, Dr C DAVIES, Dr JG Mikhalovsky, Professor S
Researcher Co-Investigators:	Dr GJ Phillips
Project Partners:	Brighton Health Care NHS Trust Mast Carbon Ltd
Department:	Sch of Pharmacy & Biomolecular Sciences
Organisation:	University of Brighton
Scheme:	Standard Research (Pre-FEC)
Starts:	01 April 2002	Ends:	30 September 2005	Value (£):	245,312
EPSRC Research Topic Classifications:	Biomaterials
EPSRC Industrial Sector Classifications:	Construction Healthcare
Related Grants:	GR/R74123/01
Panel History:
Summary on Grant Application Form
As a consequence of Gram-ve sepsis, in which the release of endotoxin (ET) from the invading pathogens results in the stimulation of a local and then systemic inflammatory response, many patients develop multi-organ dysfunction syndrome (MODS). The prognosis for such patients is poor with a UK mortality rate of upto 3000 p.a. Attempts to moderate the inflammatory response have proved disappointing. Clearly a new approach is needed to combat this condition as the removal of individual inflammatory mediators (IM's) has little effect on the remainder of the cascade. It is increasingly acknowledged that the most rational way forward in the treatment of sepsis is to carry out a blanket removal of all IMs and the endotoxin that initially triggers the inflammatory response. We aim to develop a novel in-line 3-dimensional adsoption based filtration device for the removal of ET and IMs from the circulation of septic patients. This system will use a range of novel polymer-based pyrolysed carbons. Unlike conventional carbons the synthetic nature of our adsorbents allows the manipulation of pore size and surface chemistry, thus imparting inherent specificity. Cleansed plasma may then be returned to the patient. The aim of this technology is to improve the quality and outcome for patients with sepsis and MODs.
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Organisation Website:	http://www.bton.ac.uk