| EPSRC Reference: |
GR/R72242/01 |
| Title: |
Simple and versatile: New chiral linkages for efficient asymmetric reactions on solid phase |
| Principal Investigator: |
Procter, Professor DJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
University of Glasgow |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
04 March 2002 |
Ends: |
03 March 2004 |
Value (£): |
113,180
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Combinatorial Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The aim of this project is to develop new methods for the asymmetric solid phase synthesis of important organic compounds. Many pharmaceutical and agrochemical companies and academic research groups worldwide use solid phase synthesis to prepare compounds quickly and conveniently. Unfortunately, at present, there are few truly efficient ways of preparing chiral compounds in only one enantiomeric form on solid phase. As many biologically active molecules are chiral but only one enantiomeric form has the desired activity, it is essential synthetic chemists can prepare target compounds in an asymmetric fashion. Our studies aim to address this need.Importantly, our novel solution to this problem can not only be used in a 'classical' auxiliary manner on solid phase, but our approach can also be used in novel 'asymmetric resin-capture-release reactions'. The later approach is a hybrid technique that lies between asymmetric solid and solution phase chemistry which we believe constitutes a new direction in this area which will be of international significance.Our preliminary studies show our approaches are feasible, and that the project goals are achievable in the timescale proposed. The new chemistry will prove useful to synthetic organic chemists in industry and academia worldwide.chemistry, solid phase, synthesis, organic, asymmetric chemistry, medicine, organolanthanide, natural products
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.gla.ac.uk |