EPSRC logo

Details of Grant 

EPSRC Reference: GR/R69051/01
Title: Highly Enantioselective Catalytic Allylation of Prochiral Ketones and Related Substrates
Principal Investigator: Woodward, Professor S
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Sch of Chemistry
Organisation: University of Nottingham
Scheme: Standard Research (Pre-FEC)
Starts: 23 September 2002 Ends: 22 March 2005 Value (£): 141,223
EPSRC Research Topic Classifications:
Asymmetric Chemistry Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
No relevance to Underpinning Sectors
Related Grants:
Panel History:
Panel DatePanel NameOutcome
05 Dec 2001 Chemistry responsive December 01 Deferred
Summary on Grant Application Form
A new approach to the allylation of prochiral ketones that uses mixtures of organotin reagents has been identified in our laboratory. Preliminary results (the first 5 substrates chosenl) all show enantioselectivities of 80-90% e.e. at catalyst loadings of 9-20 mol%. The selectivity and activity of this new catalyst appears to be better that any competitor science we can identify. On the basis of these preliminary results we propose to identify the scope and utility of the present reaction and to seek for even higher selectivities and for related processes (additions to !mines and related species). This chemistry will be used in the synthesis of natural products derived from Aspergillus Sydowi and Parahigginsia sp and in the preparation of potent platelet activating factor (PAF) antagonists. The mechanisms of the catalytic reactions are to be probed by spectroscopic and density function calculation approaches.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.nottingham.ac.uk