| EPSRC Reference: |
GR/R67446/01 |
| Title: |
Bioactives materials through ultrathin surface modifications |
| Principal Investigator: |
Williams, Professor NH |
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| Department: |
Chemistry |
| Organisation: |
University of Sheffield |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
13 August 2002 |
Ends: |
12 January 2006 |
Value (£): |
181,612
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Physical Organic Chemistry |
| Tissue Engineering |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Healthcare |
| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The intimate contact between soft tissue and medical devices can cause an inflammation response with serious consequences, such as device failure. Current systemic or topical treatments do not provide a satisfactory solution, so we want to address this problem by modifying the contact surface of medical devices to make them biocompatible and to have their own localised therapeutic action. We will do this by attaching bioactive peptides to the surface of devices so inflammation is suppressed and cell adhesion encouraged. Our attachment strategy is to use calixarene derivatives that we know bind to and modify the surface properties of many materials. By virtue of low loading and simple application, this treatment has the potential to be very versatile, both for specialised devices and bulk, low cost materials. We shall establish a flexible synthetic route so that the effect of key structural features on surface attachment and bioactivity can be established and optimised. The effect of surface loading and attachment of these peptide sequences will be evaluated by assessing their impact on cell adhesion, and on the ability of cells to withstand inflammatory cytokines and oxidative stress. The ultimate aim will be to create a generic type of treatment for medical devices which encourages the selective adhesion of cells which have their inflammation response suppressed.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.shef.ac.uk |