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Details of Grant 

EPSRC Reference: GR/R61604/01
Title: Catalytic Borylation via C-H and C-F Bond Activation
Principal Investigator: Perutz, Professor R
Other Investigators:
Marder, Professor T
Researcher Co-Investigators:
Project Partners:
Department: Chemistry
Organisation: University of York
Scheme: Standard Research (Pre-FEC)
Starts: 27 May 2002 Ends: 26 September 2005 Value (£): 156,965
EPSRC Research Topic Classifications:
Catalysis & Applied Catalysis
EPSRC Industrial Sector Classifications:
Chemicals Pharmaceuticals and Biotechnology
No relevance to Underpinning Sectors
Related Grants:
GR/R61598/01
Panel History:  
Summary on Grant Application Form
Arylboronate esters and boronic acids have numerous direct uses (e. . in glucose sensors, neutron capture therapy for treatment of malignant melanoma and brain tumours) and are key intermediates in the Suzuki-Miyaura -&-catalysed cross-coupling reaction for the formation of biaryls, a widely employed methodology for pharmaceuticals synthesis and the manufacture of liquid crystals. Transition metal catalysts for the synthesis of arylboronates directly from arenas, fluoroarenes and their heteroarene analogues (the simplest starting materials, yet the most difficult to functionalise) via C-H and C-F activation will be developed as a cost effective general route to these commercially important compounds. Stoichiometric reactivity of novel metal-boryl and metal-aryl compounds along with reaction kinetics and mechanistic studies of individual steps related to the catalytic processes will be studied to obtain a better understanding of the fundamental aspects of this chemistry, and these results will be used to guide catalyst development and optimisation. Modem methods of rapid parallel catalyst screening will also be employed to improve the efficiency by which suitable candidates for more detailed analysis can be identified. The combination of parallel screening with mechanistic studies is an extremely powerful approach to catalyst development which we have found to be highly successful in the past...
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Organisation Website: http://www.york.ac.uk