| EPSRC Reference: |
GR/R59359/01 |
| Title: |
Kinetic and Mechanistic Studies on the Assembly of Fe-S-Based Clusters. |
| Principal Investigator: |
Henderson, Professor RA |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
School of Chemistry |
| Organisation: |
Newcastle University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2002 |
Ends: |
30 September 2005 |
Value (£): |
76,874
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Chemical Structure |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Related Grants: |
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| Panel History: |
| Panel Date | Panel Name | Outcome |
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22 Oct 2001
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Chemistry Single Panel
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Deferred
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Summary on Grant Application Form |
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The prime goals of this project are: (i) to investigate the kinetics and mechanism of assembly of synthetic cuboidal Fe-S-based clusters of the type [MFe3S4(SR)3}2(-SR)3]3- (M = V, Mo or W) from structurally well-defined mononuclear precursors and, (ii) synthesise new functionalised clusters containing bound nitrogenous or hydrocarbon residues, their characterisation using X-ray crystallography, and investigation of the protonation chemistry of the ligands. Preliminary studies using NMR spectroscopy have identified the key intermediates in the assembly reaction. Preparation of the identified major intermediates and kinetic studies on their interconversions using rapid reaction techniques will establish the details of each step in the assembly. By piecing together these individual studies the mechanism of the total assembly will be established.One of the key steps in the assembly reaction is the formation of cuboidal (MFe3S4) clusters by reductive incorporation of a metal ion into a (Fe3S4) fragment. This reaction will be used to prepare new clusters. Mononuclear metal complexes containing nitrogenous or hydrocarbon residues will be reacted with [(RS)FeS2FeS2Fe(SR)2]3- to produce clusters in which the incorporated metal retains the nitrogenous or hydrocarbon residue. Subsequent studies will explore the protonation chemistry of the ligands bound to an Fe-S-based site.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.ncl.ac.uk |