EPSRC logo

Details of Grant 

EPSRC Reference: GR/R59298/01
Title: Structural Development and Optimisation Of Sol-Gel Derived Bioactive Glasses
Principal Investigator: Smith, Professor ME
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Physics
Organisation: University of Warwick
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2002 Ends: 31 March 2004 Value (£): 107,177
EPSRC Research Topic Classifications:
Biomaterials Materials Characterisation
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/R57508/01 GR/R57492/01
Panel History:  
Summary on Grant Application Form
Comparative studies of various compositions of bio-active glasses, ceramics and glass ceramics have established that there is a considerable range of levels of bioactivity, as measured by rates of bone bonding to bulk implants, or the rate of bone proliferation in the presence of bioactive particulates. A very limited range of bioactive glass compositions exhibit a high bioactivity index and bond to both bone and soft connective tissues; the biological response to bioactive gel-glasses made from the Ca0-Si02-P205 system provides evidence that tissue regeneration is possible, at least in bone. A fundamental understanding of the structural development and the relationship of structure to properties are called for: this proposal will apply an advanced chemical physics based materials characterisation methodology to examine a range of biomaterials of fundamental interest. The proposed research programme centres on the exploratory study of the structural properties of an important set of gel-produced bio-active materials on the atomic (1-10A) scale using an extensive characterisation methodology based upon state-of-the-art MAS NMR equipment and world-class neutron and X-ray facilities. The work will involve in-situ/time-resolved studies of key stages in the materials processing, and be explicitly focused on providing an improved understanding of their bio-active properties. This project will concentrate on Ca0-Si02 materials as there are existing medical uses and some fundamental structural questions related to the environment of calcium in silica, with extension to systems with small additions of phosphorus.
Key Findings
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Potential use in non-academic contexts
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Impacts
Description This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Summary
Date Materialised
Sectors submitted by the Researcher
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
Project URL:  
Further Information:  
Organisation Website: http://www.warwick.ac.uk