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Details of Grant 

EPSRC Reference: GR/R59298/01
Title: Structural Development and Optimisation Of Sol-Gel Derived Bioactive Glasses
Principal Investigator: Smith, Professor ME
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department: Physics
Organisation: University of Warwick
Scheme: Standard Research (Pre-FEC)
Starts: 01 April 2002 Ends: 31 March 2004 Value (£): 107,177
EPSRC Research Topic Classifications:
Biomaterials Materials Characterisation
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
GR/R57492/01 GR/R57508/01
Panel History:  
Summary on Grant Application Form
Comparative studies of various compositions of bio-active glasses, ceramics and glass ceramics have established that there is a considerable range of levels of bioactivity, as measured by rates of bone bonding to bulk implants, or the rate of bone proliferation in the presence of bioactive particulates. A very limited range of bioactive glass compositions exhibit a high bioactivity index and bond to both bone and soft connective tissues; the biological response to bioactive gel-glasses made from the Ca0-Si02-P205 system provides evidence that tissue regeneration is possible, at least in bone. A fundamental understanding of the structural development and the relationship of structure to properties are called for: this proposal will apply an advanced chemical physics based materials characterisation methodology to examine a range of biomaterials of fundamental interest. The proposed research programme centres on the exploratory study of the structural properties of an important set of gel-produced bio-active materials on the atomic (1-10A) scale using an extensive characterisation methodology based upon state-of-the-art MAS NMR equipment and world-class neutron and X-ray facilities. The work will involve in-situ/time-resolved studies of key stages in the materials processing, and be explicitly focused on providing an improved understanding of their bio-active properties. This project will concentrate on Ca0-Si02 materials as there are existing medical uses and some fundamental structural questions related to the environment of calcium in silica, with extension to systems with small additions of phosphorus.
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Organisation Website: http://www.warwick.ac.uk