| EPSRC Reference: |
GR/R54675/01 |
| Title: |
Thiolated Oligomers as Building Blocks for Hollow Nanospheres. |
| Principal Investigator: |
Chechik, Professor V |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of York |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
62,542
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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The proposed research explores a new strategy for the synthesis of hollow nanosperes 2-50 nm in diameter. The strategy is based on using Aunanoprticles as templates and thiolated oligomers as building blocks. Our method relies on the simulataneous oxidation of the Au template and formation of multiple S-S bridges which allows one-step synthesis of nanocapsules. We have just published preliminary results which confirm the feasibility of this method.We will expand this new method to synthesise and characterise a range of nanocapsules of diffrent sizes. Functionalisation of the external surface will allow us to tune their solubility and polarity. For instance, capsules perpared from mercaptomethyl styrene/styrene sufonate co-polymers, would have a hydrophilic exterior created by sulfonate groups, and hydrophobic interior dominated by S-S bonds.We will explore the host-guest properties of nanocapsules. Particular attention will be paid to the use of pyrene probes and other dyes to study the permeability of the capsule walls. Disproportionation of S-S bonds, leading to the destruction of capsules, will be studied as a means of controlled reselase of encapsulated guests.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.york.ac.uk |