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Details of Grant 

EPSRC Reference: GR/R53098/01
Title: Michaelis-Menten Type Kinetics for Non-Isolated Enzyme-Catalsed Reactions
Principal Investigator: Davidson, Professor FA
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Scottish Crop Research Institute (The)
Department: Mathematics
Organisation: University of Dundee
Scheme: Fast Stream
Starts: 07 January 2002 Ends: 06 July 2003 Value (£): 60,709
EPSRC Research Topic Classifications:
Chemical Biology Mathematical Analysis
Non-linear Systems Mathematics Numerical Analysis
EPSRC Industrial Sector Classifications:
Environment Chemicals
Related Grants:
Panel History:  
Summary on Grant Application Form
Enzyme-catalysed biochemical reactions are ubiquitous in living systems. In almost all situations, these reactions form a large interconnected network where one reaction depends on input from other reactions as well as on the environment in which the reaction takes place. Mathematical modelling has been used extensively to study these reactions. In particular, Michaelis-Menten type kinetics are commonly employed. However, the mathematical derivation of these kinetics assumes that the reaction being modelled takes place in isolation i.e. without input. In this work we propose to study the influence of external elements on the formulation of Michealis-Menten type kinetics. This will lead to a better understanding of how these reactions operate in their natural context. In particular we aim to determine conditions for the validity of Michaelis-Menten type kinetics under the action of substrate input. Moreover, we will study the effects of coupling substrate input with substrate diffusion. This work is of a basic scientific nature. However, if significant differences arise in the formulaiton of isolated and non-isolated reaction kinetics, the application of traditional Michaelis-Menten theory to in vivo systems will have to be further reviewed. Furthermore, advances in the understanding of non-isolated enzyme-catalysed reactions may in the longer term have significant impact on a wide range of biological applications and hence contribute to timely commercial and ethical issues (eg. genetic modification)
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Organisation Website: http://www.dundee.ac.uk