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Details of Grant 

EPSRC Reference: GR/R43860/01
Title: Control and Scale-Up of Batch Crystallisation Processes for Organic Speciality Chemical Products
Principal Investigator: Roberts, Professor KJ
Other Investigators:
LAI, Dr X Wang, Professor X Hammond, Dr RB
Mahmud, Dr T
Researcher Co-Investigators:
Project Partners:
AstraZeneca Bede Scientific Instruments Ltd GlaxoSmithKline plc (GSK)
Hazard Evaluation Laboratory Ltd Malvern Instruments Ltd Mitsubishi
Pfizer Ricardo Group Syngenta
Department: Chemical Engineering
Organisation: University of Leeds
Scheme: Standard Research (Pre-FEC)
Starts: 01 March 2002 Ends: 30 November 2006 Value (£): 969,560
EPSRC Research Topic Classifications:
Particle Technology
EPSRC Industrial Sector Classifications:
Chemicals
Related Grants:
GR/R43877/01 GR/R43853/01
Panel History:  
Summary on Grant Application Form
The overall objective of this programme, which forms the second phase of the Chemicals Behaving Badly (CBB) initiative, is to produce a generic but molecule-centred approach for the manufacture of speciality organic products having the required molecular and solid-phase properties, which will be achieved by identifying, measuring, exploiting and controlling the key process 'effect' parameters. It will expand the world class batch crystallisation research facilities already set-up In the first phase of the COB programme for on-line monitoring and reactor hydrodynamic modelling extending current capabilities via the incorporation of parameter analysis for subsequent control of processing factors that are particularly important In the manufacture of speciality particulate materials, e.g. molecular structure, particle morphology and product form in relation to reactor mixing and mother phase composition. The latter will involve the development of control algorithms, which shall be sufficiently robust to enable scale up or down by 2 orders of magnitude from a 20 litre laboratory standard. The emphasis will be on the production of particulate materials, which are Inherently badly behaved, i.e., large complex organic molecules with wide meta-stable zone widths, which do not nucleate or crystallise easily.
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Further Information:  
Organisation Website: http://www.leeds.ac.uk