| EPSRC Reference: |
GR/R41088/01 |
| Title: |
Theranostics: Point-of-care Quantitative Drug Metabolite Tests |
| Principal Investigator: |
Randle, Dr BJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Obstetrics |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 2001 |
Ends: |
29 February 2004 |
Value (£): |
192,105
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Instrumentation Eng. & Dev. |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Healthcare costs are increasingly being mitigated by using diagnostics to target therapeutic intervention in a cost-effective manner. We propose research for a simple, non-invasive quantitative drug metabolite measurement for use on site in drug dependency clinics and within novel pharmaceutical trials. The objective is rapid unequivocal test results at the point-of-care, a first step to design of specific treatments, customised to individual patient needs. Our consortium brings together skills in clinical medicine, synthetic chemistry, medical physics, biotechnology, pharmaceutical drug discovery and patient management. Our prototype will utilise the recently discovered ability of antibodies to control light emission from dyes. Fluorescent light emission from fluorescein can be completely extinguished, with reactions occurring in solution, providing a single phase report of antibody binding measurable by fluorimetry. We will research incorporation of this generic reporting signal into homogeneous detection systems. Work on fluorimetry will measure and enhance this diagnostic signal as appropriate. Software will create the user-assay interface and we will evaluate the prototype test at the point-of-care, the daily clinic. Our project will be considered successful without reservation on production of clinically-relevant data in a form suitable to aid decision making in patient management.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |