Details of Grant 

EPSRC Reference:	GR/R40203/01
Title:	Tumourigenesis and the Angiogenic Switch
Principal Investigator:	Sleeman, Professor B
Other Investigators:
Researcher Co-Investigators:
Project Partners:
Department:	Applied Mathematics
Organisation:	University of Leeds
Scheme:	Standard Research (Pre-FEC)
Starts:	01 October 2001	Ends:	30 November 2001	Value (£):	3,793
EPSRC Research Topic Classifications:	Non-linear Systems Mathematics
EPSRC Industrial Sector Classifications:	No relevance to Underpinning Sectors
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Panel History:
Summary on Grant Application Form
Angiogenesis is the process wherby a capillary network is formed from a pre-existing vascular network. The capillary network is largely composed of migrating endothelial cells (EC's), which organize themselves into dendritic structures. Angiogenesis is fundamental to the formation of blood vessels during placental growth, in wound healing and in tumour progression. The complexity of the process suggests the existence of multiple controls. It is now ell established that EC respond to a variety tumour secreted growth factors and growth inhibitors. The principle of Angiogenesis, being essential for the rapid expansion of tumour mass, raises the question as to whether Angiogenesis is an inevitable consequence or there is a controlling angiogenic switch (AS) which is an important part of the repertoire of properties that a development tumour must acquire to be successful. Recent experiments provide considerable evidence to suggest that Angiogenesis is regulated both by inducers and inhibitors of EC proliferation and migration. Based on Chemical Kinetics and the theory of Reinforced random walks mathematical models are being developed to gain understanding of the AS. It is hoped that the model will explain the function of the AS and suggest possible therapeutic strategies whereby tumour progression can be supressed.
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Organisation Website:	http://www.leeds.ac.uk