| EPSRC Reference: |
GR/R36398/01 |
| Title: |
Controlling chiral topology in metal complexes for enantioselective catalysis. |
| Principal Investigator: |
Scott, Professor P |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Warwick |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
174,570
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| EPSRC Research Topic Classifications: |
| Asymmetric Chemistry |
Catalysis & Applied Catalysis |
| Co-ordination Chemistry |
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| EPSRC Industrial Sector Classifications: |
| Manufacturing |
Chemicals |
| Pharmaceuticals and Biotechnology |
No relevance to Underpinning Sectors |
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| Related Grants: |
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Summary on Grant Application Form |
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The shape of the active site in a catalyst exerts a profound effect on its ability to control the stereochemical outcome of a reaction. In enantioselectiv catalysis, the traditional approach is to use chiral ligands, but it is also possible that if the ligands can be arranged about the metal in a chiral array ff stereoselective catalysis may be effected. The proposal suggests a way of combining the advantages of the two systems, by using ligands which arE inherently chiral to engender topological asymmetry. One outcome of this may be, by analogy with the mechanism of selctivity in many biological systems, a type of induced-fit mechanism, where the reagents mould the active site in a manner allowed by the ligands. We have preliminary results that indicate how this type of catalyst might be achieved, and have produced complexes which have very well expressed topological chirality and twc cis-oriented sites for catalysis. We will synthesise a range of ligands for this purpose based on a directional bidentate monoanionic design i.e. (A-B)with various donor atoms N, O and P. Strategies for toplogical control in non-racemic C2-symmetric architectures are proposed. Complexes targette, include candidate catalysts for enantioselective imine reduction, epoxidation and carbene reactions. For these catalysis studies, complexes of e.g. Z Mn and Ru will be synthesised.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.warwick.ac.uk |