| EPSRC Reference: |
GR/R31577/01 |
| Title: |
Advanced Biocompatible Endovascular Stents |
| Principal Investigator: |
Rand, Professor B |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Institute of Materials Research |
| Organisation: |
University of Leeds |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 September 2001 |
Ends: |
31 August 2004 |
Value (£): |
263,543
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| EPSRC Research Topic Classifications: |
| Materials Characterisation |
Materials Processing |
| Medical science & disease |
Tissue Engineering |
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| Panel History: |
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Summary on Grant Application Form |
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The biocompatibility of the currently available coronary stems is compromised by thrombus formation and excessive intimal proliferation leading to in-stmt stenosis. In addition the highly corrosive in vivo environment results in gradual release of metal ions into the blood stream. A significant improvement of stmt biocompatibility is needed to reduce the rate of intrastent restenosis and target vessel revascularisation. Such an improvement can be achieved either by (I) surface modification of currently existing stems; (2) novel stmt design, or by (3) using new materials for stmt design. This multi-centred interdisciplinary project involving surface engineers, chemists, cell biologists, material scientists, clinicians and industrial partners aims to address these problems through the development of novel stmt coatings with improved biocompatibility. The project will involve an iterative process of stem coating and in vitro bioevalaution to determine the relationship between surface interfacial properties and material compatibility in this application. Optimised systems will be evaluated in a limited animal study to provide preliminary data to support subsequent product commercialisation through the industrial partners.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |