| EPSRC Reference: |
GR/R30341/01 |
| Title: |
Preparation and Characterisation of Amorphous Pharmaceutical Blends From Libraries of Polymers. |
| Principal Investigator: |
Brocchini, Professor SJ |
| Other Investigators: |
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| Project Partners: |
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| Department: |
School of Pharmacy |
| Organisation: |
UCL |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
192,271
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| EPSRC Research Topic Classifications: |
| Drug Formulation & Delivery |
Materials Characterisation |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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The main focus of enquiry for the research described in this proposal is to use two polymer precursor systems to prepare and characterise libraries of functionalised polymers as excipients. These functionalised excipients are designed to possess certain elements of defined structure such as (1) narrow molecular weight distribution or (2) strictly alternating main chain structure. The basis for using the polymer precursors is to examine how a combinatorial paradigm can be used in biomedical polymer development to (1) optimise structure-property correlations and (2) to deconvolute properties due to processing history from properties due to chemical structure. We intend to use the libraries of polymers (40-50 members) to prepare libraries of amorphous blends (i.e. pharmaceutical formulations) which will be concisely characterised. A major issue of the proposed research is to determine the multivariant structure-property correlations and how they map onto the processing history of preparing the amorphous blends. The amorphous blends will be prepared by spray drying under defined conditions of temperature, feed rate, concentration, solvent and atmosphere. The primary purpose of this application is to investigate and exploit the polymer precursors we have on hand to systematise the development and selection of functionalised, speciality biomedical polymers as excipients and coating materials.
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Key Findings |
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Potential use in non-academic contexts |
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Impacts |
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| Description |
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| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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