| EPSRC Reference: |
GR/R26313/01 |
| Title: |
Controlled Release of Ag From Antimicrobial Bioactive Gel-Glasses. |
| Principal Investigator: |
Hench, Professor L |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Materials |
| Organisation: |
Imperial College London |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 May 2001 |
Ends: |
31 October 2004 |
Value (£): |
147,076
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Drug Formulation & Delivery |
| Materials Characterisation |
Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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A recent disvoery in our lab shows that Ag-doped bioactive gel-glasses slowly release Ag+, a power ful antibacterial agent, at very low (PPM) concentrations. This unique gel-glass has an inhibitory effect on growth of gram(+)and gram(-) bacteria with cell populations decreased 5 to 6 orders of magnitude relative to control cultures. the minimum inhibitory concentrations for E.coli, P. aeruginosa and S,. aureus are in the range of 0.05 to 0.2mg/ml. This project will establish the scientify fabsis for cotnrolling the concentration and rate of relearse of Ag from the bioactive gel-glass matrix so that the material can be used topically to comabt infections of antibiotic resistant strains of bacteria commonly associated with implant surgery. Careful control of the rate of release of the antimicrobial agent may also make it possible to use this material as a coating on protheses to prevent infection.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.imperial.ac.uk |