| EPSRC Reference: |
GR/R22735/01 |
| Title: |
(Ropa) Glycosylation With An In Situ Separation: Carbohydrate Chemistry On a Tlc Plate |
| Principal Investigator: |
Field, Dr R |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
University of East Anglia |
| Scheme: |
ROPA |
| Starts: |
21 September 2001 |
Ends: |
20 September 2002 |
Value (£): |
67,532
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| No relevance to Underpinning Sectors |
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Summary on Grant Application Form |
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Traditional oligosaccharide synthesis is hampered by the need for moisture sensitive reactants and reagents, coupled with laborious rounds of chromatographic purification. We have shown that iodine vapour can be used to active thioglycosides deposited on tlc plates (i.e. the absence of solvent). In the presence of sugar alcohols, disaccharides can be formed and subsequently separated in situ without work-up. In principle, trisaccharides could be synthesised by exploiting a second dimension of chromatography. Low-tech micro-scale synthetic chemistry on a tlc plate offers substantial scope for multiple parallel synthesis of glycoside libraries, but also suggests scope for scale-up. The aim of this project is to provide proof of concept.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.uea.ac.uk |