| EPSRC Reference: |
GR/R19564/01 |
| Title: |
Chemical Sensors Based On Molecular Imprinted Receptors and Fluorescent Transducers |
| Principal Investigator: |
Ansell, Dr RJ |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Chemistry |
| Organisation: |
University of Leeds |
| Scheme: |
Fast Stream |
| Starts: |
14 August 2001 |
Ends: |
13 January 2005 |
Value (£): |
66,679
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| EPSRC Research Topic Classifications: |
| Analytical Science |
Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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Summary on Grant Application Form |
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In the proposed project, we will develop selective fluorescent chemical sensors for specific steroids based on molecular imprinted polymers containing fluorogenic signalling groups. In order to achieve this we will combine a transduction method in which the binding of analyte leads to formation of a hydrogen and causing unquenching of fluorescence, and a new 'sacrificial spacer' imprinting approach based on carbamate adducts to ensure a 1:1 correspondence of fluorophores to recognition sites in the polymers.We will first develop polymerisable fluorophores whose fluorescence is quenched by a linked amino group. We will evaluate the sensing properties of these fluorophores in molecular imprinted polymers using (S)-naproxen as the template/analyte. We will then investigate the use of carbamate linkers in molecular imprinting, preparing steroid-amino monomer adducts, incorporating them into imprinted polymers and investigating template extraction and the selectivity of rebinding.Finally we will combine the two new technologies, preparing steroid-amino-fluorophore adducts and using them to prepare fluorescent polymer sensors for steroids.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.leeds.ac.uk |