| EPSRC Reference: |
GR/R14750/01 |
| Title: |
The Preparation of Peptide-Based Block Copolymers By Living Radical Polymerisation |
| Principal Investigator: |
Sanderson, Dr JM |
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| Department: |
Chemistry |
| Organisation: |
Durham, University of |
| Scheme: |
Fast Stream |
| Starts: |
01 October 2001 |
Ends: |
30 September 2004 |
Value (£): |
65,724
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| EPSRC Research Topic Classifications: |
| Biological & Medicinal Chem. |
Drug Formulation & Delivery |
| Materials Synthesis & Growth |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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In recent years there has been much attention directed towards the preparation of bioconjugates by the derivatisation if pre-prepared synthetic polymers with biological macromolecules using simple activation chemistry. Particular attention has been paid to peptide-polymer conjugates in which the peptide has some kind of cell signalling or recognition functionality. These systems offer great potential as drug delivery systems, but for biomedical applications it is essential that the bioconjugates are water soluble and of uniform composition. The research in this proposal focuses on a recent development in polymerisation chemistry, atom transfer radical polymerisation or ATRP, that allows water soluble polymers to be prepared under mild temperature and pH conditions. These conditions are ideal for the use of modified peptides and proteins as polymerisation initiators, leading to the eventual formation of protein-capped polymers of high uniformity. To date however, this avenue of research has remained undeveloped. This project will develop the methodology required to prepare and use peptide and protein-based initiators for ATRP. Reagents will be developed for the preparation of peptide initiators by solid-phase synthesis and protein initiators by protein chemistry. Lysozyme and a simple recognition peptide containing the RGD sequence will be used as models, as both of these systems are well characterised.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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