| EPSRC Reference: |
GR/R12084/01 |
| Title: |
Investigation of Protein Adsorption At the Liquid/Liquid Interface |
| Principal Investigator: |
Caruana, Professor D |
| Other Investigators: |
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| Department: |
Chemistry |
| Organisation: |
UCL |
| Scheme: |
Fast Stream |
| Starts: |
24 September 2001 |
Ends: |
23 September 2004 |
Value (£): |
62,923
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| EPSRC Research Topic Classifications: |
| Electrochemical Science & Eng. |
Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Food and Drink |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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A research program suitable for a PhD studentship is proposed to study the protein adsorption at the interface between two immiscible liquids. The approach proposed here involves the stabilisation of a homogenous oil-in-water (or water-in-oil) micro-emulsion without the use of surfactant. The protein decorated liquid/liquid interface produces may be studied by small angle neutron scattering (SANS). We expect to determine the interfacial structure of the protein modified interfaces in terms of layer thickness, and how this layer is effected by under different physical and chemical conditions.A novel experimental strategy is proposed for the production of an electrostatically stabilised emulsion, by the distribution of a potential determining ions across the interface. The electrochemical potential difference defined across the interface reduces the coalescence. By matching the densities of the two immiscible liquids the gravimetrically sedimentation is also reduced.The adsorption of proteins at the interface between the two phases, with and without biologically active surfactants will be studied by SANS. A total of 8 weeks of Neutron beam time has been awarded for this project spread over 2 years at the Riso National Laboratory in Denmark, through the European Union, CEC - Access to Large Installations Programme.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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