| EPSRC Reference: |
GR/R07301/01 |
| Title: |
The Development of a Magnetically Controlled Force Microscope, For High Resolution Single Molecule Force Spectroscopy |
| Principal Investigator: |
Allen, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Sch of Pharmaceutical Sciences |
| Organisation: |
University of Nottingham |
| Scheme: |
Fast Stream |
| Starts: |
01 February 2001 |
Ends: |
31 January 2004 |
Value (£): |
60,330
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| EPSRC Research Topic Classifications: |
| Cells |
Surfaces & Interfaces |
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| EPSRC Industrial Sector Classifications: |
| Healthcare |
Pharmaceuticals and Biotechnology |
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| Related Grants: |
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| Panel History: |
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Summary on Grant Application Form |
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Recent developments in optical and scanning probe microscope (SPM) techniques have significant advances in the characterization and manipulation of single molecules. However, despite such studies several limitations still hamper progress in this research field, many of which have been recently overcome through improvements in instrumentation and cantilever technologies. This proposal seeks to address the remaining limitations through the development of the current state-of -the- art atomic force microscope (AFM) instrumentation. Specifically, a newly available form of AFM, termed the molecular force-probe (MFP)(Asylum Research, CA) will be modified to enable the direct control of cantilever deflection (and hence applied force) through the application of a magnetic force. The addition benefits of the developed instrument for single biomolecule force spectroscopy studies will be investigated through a series of experiments on well characterized model biomolecular systems. In particular, these studies will aim to address key advances required in the field of biomolecular force spectroscopy.The proposed studies will build on the applicant's expertise in biomolecular force measurement field and instrumental development, and are intended to pump-prime the principal applicant's research in these areas. In addition, the outcome of this research should develop instrumentation which will impact not only on the AFM and force measurement communities, but also on the scientific fields and technologies reliant upon an fundamental understanding of biomolecular interactions.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.nottingham.ac.uk |