| EPSRC Reference: |
GR/R02382/01 |
| Title: |
The Application of a Powerful Cycloaddition Methology To the Synthesis of Stemona Alkaloids |
| Principal Investigator: |
Booker-Milburn, Professor KI |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
University of Bristol |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 July 2001 |
Ends: |
30 September 2004 |
Value (£): |
223,573
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Pharmaceuticals and Biotechnology |
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Summary on Grant Application Form |
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The work described in this proposal is aimed towards the total synthesis of four of the stemona alkaloids; Stemoamide, Stemoninoamide, Tuberostemospionine and Tuberostemonine L-G. This will be achieved using a unified strategy based on our recently uncovered [5+2] photocycloadditon reaction of maleimides to construct the perhydroazaazulene skeleton common to all four alkaloids. The photocycloaddition using chirally modified maleimide derivatives will also be investigated, which may allow asymmetric synthesis of some of these alkaloids to be achieved.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.bris.ac.uk |