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Details of Grant 

EPSRC Reference: GR/N63604/01
Title: AN INVESTIGATION INTO THE SYNTHESIS CHARACTERISATION & PERFORMANCE OF DRUG CONJUGATED PMMA BONE CEMENTS
Principal Investigator: Gorman, Professor SP
Other Investigators:
Craig, Professor D Jones, Professor DS McCoy, Professor CP
Researcher Co-Investigators:
Project Partners:
Department: Sch of Pharmacy
Organisation: Queen's University of Belfast
Scheme: Standard Research (Pre-FEC)
Starts: 18 June 2001 Ends: 17 June 2004 Value (£): 166,483
EPSRC Research Topic Classifications:
Biomaterials
EPSRC Industrial Sector Classifications:
Healthcare
Related Grants:
Panel History:  
Summary on Grant Application Form
There is a strong perceived need for the development of novel bone cement materials for total hip replacement operations, particularly in terms of developing strategies for effective antibiotic loading and release. In this investigation we intend to systhesise a range of quinolone conjugated polymethylmethacrylate (PMMA) derivative and to examine the in vitro properties of these materials in terms of drug release behaviour, physical properties and the ability to prevent biofilm growth. More specifically we plan to synthesese nalidixic acid and ciprofloxacin derivatives of PMMA using a hydrolysable ester spacer group and an intramolecular nucleoplile neighbouring moeity in order to facilitate control of the drug release rate. Dissolution testing will be performed along with physical assessment using dynamic mechanical thermal analysis, tensile testing and modulated temperature DSC. Biofilm formation on disks of the candidate materials will be examined using the Robbins device.
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Organisation Website: http://www.qub.ac.uk