| EPSRC Reference: |
GR/N36745/01 |
| Title: |
STEREOSELECTIVE REACTIONS OF HETEROBIMETALLIC ALKYNE COMPLEXES |
| Principal Investigator: |
Christie, Professor S |
| Other Investigators: |
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| Researcher Co-Investigators: |
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| Project Partners: |
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| Department: |
Chemistry |
| Organisation: |
Loughborough University |
| Scheme: |
Standard Research (Pre-FEC) |
| Starts: |
01 October 2000 |
Ends: |
30 September 2003 |
Value (£): |
73,116
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| EPSRC Research Topic Classifications: |
| Chemical Synthetic Methodology |
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| EPSRC Industrial Sector Classifications: |
| Chemicals |
Pharmaceuticals and Biotechnology |
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| Panel History: |
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Summary on Grant Application Form |
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The chemistry outlined in proposal build on our use of heterobimetallic alkyne complexes and their use in organic synthesis. Using these complexes, we can effect highly stereoselective Pauson-Khand cyclisations to produce optically enriched cyclopentenone products. This will allow us to probe the mechanism of the reaction and to predict the chirality of the organic product produced. We also wish to produce the complexes in a stereocontrolled manner through a diastereocontrolled isolobal displacement. This will be achieved using chiral groups either on the organometallic fragment (chiral cyclopentadienyl ligand) or on the alkyne (chiral auxiliary). In addition, we will use the chirality in the metal-alkyne core to control nucleophilic additions to a pendant carbonyl group. When used in combination with Pauson-Khand, we will synthesise five carbon-carbon bonds and control three new chiral centres from a single source of chirality.
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Key Findings |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Potential use in non-academic contexts |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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Impacts |
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| Description |
This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk |
| Summary |
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| Date Materialised |
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Sectors submitted by the Researcher |
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This information can now be found on Gateway to Research (GtR) http://gtr.rcuk.ac.uk
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| Project URL: |
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| Further Information: |
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| Organisation Website: |
http://www.lboro.ac.uk |